117890-55-8

Basic information

• Product Name: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine
• Synonyms: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine;2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine(SALTDATA: FREE);2-chloro-5H,6H,7H-cyclopenta[b]pyridine;2-CHLORO-6,7-DIHYDRO-5H-[1]PYRINDINE;5H-Cyclopenta[b]pyridine, 2-chloro-6,7-dihydro-;2-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridin
• CAS NO: 117890-55-8
• Molecular Formula: C8H8ClN
• Molecular Weight: 153.611
• Mol File: 117890-55-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 236.528 °C at 760 mmHg
• Flash Point: 119.643 °C
• Appearance: /
• Density: 1.242 g/cm³
• Vapor Pressure: 0.072mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.39±0.20(Predicted)
• CAS DataBase Reference: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine(117890-55-8)
• EPA Substance Registry System: 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine(117890-55-8)

Safety Data

• Hazardous Substances Data: 117890-55-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine is a chemical compound with the molecular formula C10H10ClN. It is a heterocyclic compound that contains a chloro substituent and a fused cyclopentane and pyridine ring system. 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine has potential applications in organic synthesis and pharmaceutical research, as it could serve as a building block for the synthesis of various biologically active compounds. The structure and properties of 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine make it of interest to researchers in the fields of medicinal chemistry and drug development. However, its specific uses and properties may vary depending on the context in which it is being studied.

InChI:InChI=1/C8H8ClN/c9-8-5-4-6-2-1-3-7(6)10-8/h4-5H,1-3H2

Upstream product

• 930-91-6 2-hydroxymethylenecyclopentanone 
• 120-92-3 cyclopentanone 
• 4594-77-8 2-oxocyclopentanepropiononitrile 
• 1092444-79-5 S-3-(6-chloro-3-pyridyl)-1-(trimethylsilyl)propyl O-ethyl dithiocarbonate 
• 15814-19-4 N-cyclopentylidene-1-phenylmethanamine 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 1192-54-7 2-formylcyclopentanone 
• 115122-63-9 2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carboxylic acid 
• 88499-85-8 1,5,6,7-tetrahydro-2H-cyclopentan[b]pyridin-2-one 
• 856152-69-7 7a-hydroxy-2-oxo-2,3,5,6,7,7a-hexahydro-1H-[1]pyrindine-3-carbonitrile 
• 88499-85-8 6,7-dihydro-5H-cyclopenta[b]pyridin-2-ol 

Downstream Products

• 533-37-9 2,3-cyclopentenopyridine 
• 247185-52-0 (R)-7-hydroxy-2-phenyl-6,7-dihydro-5H-<1>pyridine 
• 1140240-18-1 2-bromo-6,7-dihydro-5H-cyclopenta[b]pyridine 
• 1150617-92-7 2-chloro-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one 
• 911405-87-3 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide 
• 175410-72-7 Thiocarbonic acid O-((6S,7S)-2-chloro-7-isopropenyl-6,7-dihydro-5H-[1]pyrindin-6-yl) ester O-phenyl ester 

Relevant articles and documents

METHODS OF MAKING WEE1 INHIBITOR COMPOUNDS

The invention relates to a method of producing a WEE1 inhibitor of formula (1A) useful in the treatment of pathological conditions characterized by excessive cell proliferation, such as cancer. In some embodiments, the invention relates to methods for producing intermediate compounds of formulas (3), (5) and (6) as defined in the description.

Method for synthesizing chiral nitrogen-phosphorus ligand L-8 containing pyridocycloheptane

The invention discloses a method for synthesizing a chiral nitrogen-phosphorus ligand L-8 containing pyridocycloheptane, and belongs to the technical field of medical intermediate chiral ligands. Thechiral nitrogen-phosphorus L-8 ligand is prepared from cyclopentanone through the steps of addition, cyclization, chlorination, asymmetric boronation, oxidation, coupling, esterification and the likein sequence, large-scale preparation is relatively easy to achieve through the route, and the defect that in a traditional route, the yield is low in the first step of ring closing reaction and chiralalcohol preparation, and by selecting a proper chiral ligand, and combining with butyl lithium, asymmetric synthesis of chiral alcohol is realized, and a chiral separation column mode adopted in literature is avoided.

Production process of 2,3- cyclopenteno pyridine

2,3-cyclopenteno pyridine has physiological activity of resisting ulcer and resisting cancer, is an important medical intermediate and alkaloid, is also used for preparing plant protective agents, synthetic resin, antioxidants and the like, and is currently used for the side chains of a fourth-generation injection-use aminothiazole cephalosporins, which is cefpirome, and the quantity demanded in developing countries, such as China and India, is growing rapidly at present. The invention provides a production process of the 2,3- cyclopenteno pyridine. The specific process is as follows: (1) preparation of 4,5,6,7-tetrahydro-2-oxo-3-formyl cyclopenteno pyridine, (2) preparation of 2-chloro-2,3-cyclopenteno pyridine, and (3) preparation of the 2,3-cyclopenteno pyridine.