117890-81-0

Basic information

• Product Name: 4-Chloro-7-methyl-pyrido[2,3-d]pyrimidine
• Synonyms: 4-Chloro-7-methyl-pyrido[2,3-d]pyrimidine
• CAS NO: 117890-81-0
• Molecular Formula: C₈H₆ClN₃
• Molecular Weight: 180
• Mol File: 117890-81-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 4-Chloro-7-methyl-pyrido[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-7-methyl-pyrido[2,3-d]pyrimidine(117890-81-0)
• EPA Substance Registry System: 4-Chloro-7-methyl-pyrido[2,3-d]pyrimidine(117890-81-0)

Safety Data

• Hazardous Substances Data: 117890-81-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-7-methyl-pyrido[2,3-d]pyrimidine is used as a key intermediate in the synthesis of pharmaceuticals for its potential as an antineoplastic agent. It contributes to the development of compounds that target cancer cells, offering a promising avenue for cancer treatment.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-7-methyl-pyrido[2,3-d]pyrimidine serves as a chemical building block in the creation of agrochemicals. It is utilized in the synthesis of various compounds with biological activity, which can be applied in pest control and crop protection to enhance agricultural productivity.
Used in Medicinal Chemistry and Drug Discovery:
4-Chloro-7-methyl-pyrido[2,3-d]pyrimidine is employed as a valuable component in medicinal chemistry for its potential to be incorporated into novel drug candidates. Its unique structure allows for the exploration of new therapeutic agents, particularly those with antineoplastic properties, thus contributing to the advancement of drug discovery.

Upstream product

• 116598-87-9 7-methyl-pyrido[2,3-d]pyrimidin-4-ol 
• 846021-26-9 2-amino-6-methyl nicotinic acid 
• 30529-70-5 2-chloro-6-methyl nicotinic acid 

Downstream Products

• 853680-63-4 (7R)-4-[7-methyl-8-(3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 853680-62-3 (7S)-4-[7-methyl-8-(3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 853680-66-7 (7S,2R)-{1-(4-chlorobenzyl)-2-[4-(7-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.