1178903-52-0

Basic information

• Product Name: (3R)-tert-butyl 3-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ylamino)piperidine-1-carboxylate
• Synonyms: (3R)-tert-butyl 3-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ylamino)piperidine-1-carboxylate
• CAS NO: 1178903-52-0
• Molecular Weight: 400.521
• Mol File: 1178903-52-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R)-tert-butyl 3-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ylamino)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-tert-butyl 3-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ylamino)piperidine-1-carboxylate(1178903-52-0)
• EPA Substance Registry System: (3R)-tert-butyl 3-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ylamino)piperidine-1-carboxylate(1178903-52-0)

Safety Data

• Hazardous Substances Data: 1178903-52-0(Hazardous Substances Data)

Upstream product

• 188111-79-7 tert-butyl (3R)3-aminopiperidine-1-carboxylate 
• 1178903-21-3 5-bromo-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole 
• 76144-87-1 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl 

Relevant articles and documents

Indazoles: Regioselective protection and subsequent amine coupling reactions

(Chemical Equation Presented) Indazoles are unselectively protected under strongly basic conditions to give a mixture at N-1 and N-2. Under mildly acidic conditions, regioselective protection at N-2 takes place. Thermodynamic conditions lead to regioselective protection at N-1. This trend applies to various substituted indazoles. Protected 5-bromoindazoles participate in Buchwald reactions with a range of amines to generate novel derivatives.