117902-12-2Relevant academic research and scientific papers
FACILE PREPARATIONS OF 4-FLUORORESORCINOL
Belanger, Patrice C.,Lau, C. K.,Williams, Haydn W. R.,Dufresne, C.,Scheigetz, John
, p. 1479 - 1482 (2007/10/02)
Two facile methods for preparing 4-fluororesorcinol have been developed.In the first method, the direct fluorination of 1,3-dimethoxybenzene with trifluoromethyl hypofluorite carried out in Freon 11 at -78 deg C afforded 2,4-dimethoxyfluorobenzene.Demethylation by heating under reflux in 48percent HBr in acetic acid gave 4-fluororesorcinol in an overall yield of 60percent.The second method involved the fluorination of 2,6-dimethoxycetophenone by trifluoromethyl hypofluorite in Freon 11 at -78 deg C, leading to 2,6-dimethoxy-3-fluorocetophenone.On heating under reflux in 48percent HBr in acetic acid, 4-fluororesorcinol was obtained in an overall yield of 74percent.The latter is the method of choice for preparing 4-fluororesorcinol.
