117902-16-6

Usage

Uses

Used in Organic Chemistry Research:
2-Fluoro-5-methoxyphenol is used as a research compound for the development of new chemical entities. Its unique structure allows for the exploration of its reactivity and potential applications in various chemical reactions.
Used in Pharmaceutical Industry:
2-Fluoro-5-methoxyphenol is used as a building block in the synthesis of pharmaceutical compounds. Its presence in the molecular structure can influence the properties and activity of the final drug product, making it a valuable component in drug discovery and development.
Used in Material Science:
2-Fluoro-5-methoxyphenol is used as a precursor in the synthesis of advanced materials, such as polymers and coatings, that exhibit specific properties like enhanced stability or improved performance in various applications.
Used in Agrochemical Industry:
2-Fluoro-5-methoxyphenol is used as a starting material in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties can contribute to the effectiveness and selectivity of these products in controlling pests and weeds in agricultural settings.

Upstream product

• 17715-70-7 1,3-dimethoxy-4-fluorobenzene 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 151-10-0 1,3-Dimethoxybenzene 
• 2237-36-7 4-methoxysalicylic acid 
• 406482-19-7 2-fluoro-5-methoxyphenylboronic acid 
• 150-19-6 O-methylresorcine 
• 121-43-7 Trimethyl borate 

Downstream Products

• 951793-93-4 (2-fluoro-5-methoxyphenoxy)triisopropylsilane 
• 170482-99-2 3-fluoro-2-hydroxy-6-methoxybenzaldehyde 
• 883576-31-6 2-Fluoro-3-hydroxy-5-methoxybenzaldehyde 
• 951805-75-7 carbonic acid 2-{3-[(4-cyanophenylamino)-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]-triazol-3-yl)methyl]-2-fluoro-5-methoxyphenoxy}ethyl ester methyl ester 
• 1350551-52-8 3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester methanesulfonate 
• 1350551-55-1 3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester hydrochloride 
• 1350551-56-2 3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester ethanesulfonate 
• 1350551-57-3 3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester propanesulfonate 
• 1350551-60-8 4-{[cyano(2-fluoro-3-hydroxy-5-methoxyphenyl)methyl]amino}benzonitrile 
• 1350551-61-9 4-({cyano[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}amino)benzonitrile 
• 1350551-62-0 2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide 
• 1362252-60-5 2-fluoro-3-(2-hydroxyethoxy)-5-methoxybenzaldehyde 
• 1350551-63-1 2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester 
• 1350551-64-2 carbonic acid {3-[1-(4-cyanophenylimino)-2-methoxycarbonylimino-2-methylsulfanylethyl]-2-fluoro-5-methoxyphenoxy}ethyl ester methyl ester 

Relevant academic research and scientific papers

Derivatives of m-Guaiacol, Their Preparation and Their Uses

The invention concerns derivatives of m-guaiacol, their preparation and their uses as biocides, in particular as antibacterials or disinfectants.

Phenol compound ortho-position direct fluorination method

The invention relates to a phenol compound ortho-position direct fluorination method which comprises the following steps: reacting a phenol compound shown in a formula (1A) with a fluorination reagentin a solvent under the action of a photocatalyst and a light source at room temperature, and separating and purifying a reaction mixture after the reaction to obtain a fluorinated phenol compound shown in a formula (2A). The advantages are as follows: the method for directly fluorinating phenol by organic photocatalysis is simple in operation process; raw materials are commercialized and easy toobtain; the photocatalyst is low in price, easy to obtain and environmentally friendly; the reaction condition is mild; the site selectivity is high; the reaction is efficient; and a fluorinated phenol derivative can be prepared only through one step.

A practical method for preparation of phenols from arylboronic acids catalyzed by iodopovidone in aqueous medium

A novel and efficient strategy for the ipso-hydroxylation of arylboronic acids to phenols has been developed using inexpensive, readily available, air-stable water-soluble povidone iodine as catalyst and aqueous hydrogen peroxide as oxidizing agent. The reactions were performed at room temperature under metal-, ligand- and base-free condition in a short reaction time. The corresponding substituted phenols were obtained in moderate to good yields by oxidative hydroxylation of arylboronic acids in aqueous medium.

Decarboxylative Fluorination of Arylcarboxylic Acids Promoted by ortho-Hydroxy and Amino Groups

A novel decarboxylative fluorination process has been developed for the synthesis of ortho-hydroxy/amino arylfluorides from salicylic acid analogs, in which the ortho-hydroxy/amino group plays an important role in the transformation. In addition, various arylfluorides are obtained in good to excellent yields under mild conditions.

3,5-DISUBSTITUTED PYRAZOLES USEFUL AS CHECKPOINT KINASE 1 (CHK1) INHIBITORS, AND THEIR PREPARATIONS AND APPLICATIONS

Potent inhibitors of Chk1 have the structure formula (I) below. Pharmaceutical compositions comprising the Chk1 inhibitors, uses thereof and their preparation process.

PRODRUG OF TRIAZOLONE COMPOUND

By oral administration of a compound represented by the following Formula (I): the blood level of Compound (IV): which has an excellent inhibitory action against blood coagulation factor VIIa and the anticoagulant action, reaches a level sufficient for ex

2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES

A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.]

Triazolone derivatives

A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochem

CHROMAN DERIVATIVES

3-amino-5-carbamoylchromans and 8-fluoro-3-amino-5-carbamoylchromans, as well as enantiomers and salts thereof, are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptamine-mediated disorders of the central nervous system.

FACILE PREPARATIONS OF 4-FLUORORESORCINOL

Two facile methods for preparing 4-fluororesorcinol have been developed.In the first method, the direct fluorination of 1,3-dimethoxybenzene with trifluoromethyl hypofluorite carried out in Freon 11 at -78 deg C afforded 2,4-dimethoxyfluorobenzene.Demethylation by heating under reflux in 48percent HBr in acetic acid gave 4-fluororesorcinol in an overall yield of 60percent.The second method involved the fluorination of 2,6-dimethoxycetophenone by trifluoromethyl hypofluorite in Freon 11 at -78 deg C, leading to 2,6-dimethoxy-3-fluorocetophenone.On heating under reflux in 48percent HBr in acetic acid, 4-fluororesorcinol was obtained in an overall yield of 74percent.The latter is the method of choice for preparing 4-fluororesorcinol.