117905-47-2

Usage

Uses

Used in Water Treatment Industry:
1-(1-oxopentyl)piperazine is used as a corrosion inhibitor for protecting metal surfaces from degradation in water treatment processes. Its effectiveness in inhibiting corrosion makes it a valuable component in maintaining the integrity of water infrastructure and equipment.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 1-(1-oxopentyl)piperazine serves as a reactive intermediate in the development of various medications. Its unique chemical structure allows it to be a key building block in the synthesis of a range of pharmaceutical compounds, contributing to the advancement of medical treatments.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical sector, 1-(1-oxopentyl)piperazine is utilized as an intermediate in the production of different agrochemicals. Its role in the synthesis of these chemicals aids in the development of products that enhance agricultural productivity and protect crops from pests and diseases.

Upstream product

• 314728-82-0 4-benzyl-1-pentanoylpiperazine 
• 638-29-9 n-valeryl chloride 

Relevant academic research and scientific papers

New antiproliferative benzoindolinothiazepines derivatives

New benzoindolinothiazepines containing a piperazine moiety are described as potent antiproliferative agents against PC3 human prostatic cell lines. This activity could be explained by an accumulation of cells in G1 phase.

Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity

Several 4-substituted 1-acylpiperazines, obtained by molecular simplification of 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones, have been synthesized and tested in vivo on the mouse passive avoidance test, to evaluate their nootropic activity. The results show that, apparently, an N-acylpiperazine group can mimic the 2-pyrrolidinone ring of 1,4-diazabicyclo[4.3.0]nonan-9-one, as the compounds of the new series maintain high nootropic activity. Moreover molecular simplification produces more clear-cut structure-activity relationships with respect to the parent series. The mechanism of action also appears to be similar in the two series. In fact, although the molecular mechanism remains to be elucidated, the most potent compound of each class (DM232 and 13, DM235) is able to increase acetylcholine release in rat brain. Piperazine derivatives represent a new class of nootropic drugs with an in vivo pharmacological profile very similar to that of piracetam, showing much higher potency with respect to the reference compound. Among the compounds studied, 13 (DM235) shows outstanding potency, being active at a dose of 0.001 mg kg-1 sc.

Transdermal compositions of 1-oxohydrocarbyl-substituted azacyclohexanes

This invention provides compositions for enhancing penetration of physiologically active agents through the skin or mucosal membranes and for retaining these agents in body tissues, said composition comprising effective amounts of a physiologically-active agent and a compound represented by the general formula STR1 wherein X may represent sulfur, oxygen or nitrogen; a and b may be 0 or 1, c may be 0, 1 or 2, except that when X is oxygen, a, b and c are 0, when X is nitrogen c is 0 and only one of a or b is 1, and when X is sulfur a and b are 0; A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkanoyl; and R is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, STR2 wherein R" is H or halogen, and salts, e.g. acid or quaternary derivatives, thereof. These compositions are useful in topical or transdermal applications of the physiologically-active agent.