117918-58-8

Basic information

• Product Name: 1-(THIOPHENE-2-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID
• Synonyms: N-(2-Thiophenecarbonyl)-L-proline
• CAS NO: 117918-58-8
• Molecular Formula: C10H11NO3S
• Molecular Weight: 225.27
• Mol File: 117918-58-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 445.3°Cat760mmHg
• Flash Point: 223.1°C
• Appearance: /
• Density: 1.421g/cm³
• Vapor Pressure: 1.03E-08mmHg at 25°C
• CAS DataBase Reference: 1-(THIOPHENE-2-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(THIOPHENE-2-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID(117918-58-8)
• EPA Substance Registry System: 1-(THIOPHENE-2-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID(117918-58-8)

Safety Data

• Hazardous Substances Data: 117918-58-8(Hazardous Substances Data)

Usage

General Description

1-(Thiophene-2-carbonyl)-pyrrolidine-2-carboxylic acid is a chemical compound that consists of a pyrrolidine ring with a carbonyl group attached to the thiophene ring at the 1 position and a carboxylic acid group attached to the pyrrolidine ring at the 2 position. 1-(THIOPHENE-2-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID is a heterocyclic compound and belongs to the class of organic compounds known as heteroaromatic compounds. It is commonly used in organic synthesis and medicinal chemistry. 1-(THIOPHENE-2-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID may have potential applications in pharmaceutical research and drug development due to its structural features. Furthermore, it can be used as a building block for the synthesis of biologically active molecules.

InChI:InChI=1/C10H11NO3S/c12-9(8-4-2-6-15-8)11-5-1-3-7(11)10(13)14/h2,4,6-7H,1,3,5H2,(H,13,14)/p-1/t7-/m0/s1

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 147-85-3 L-proline 
• 527-72-0 2-thiophenylcarboxylic acid 

Relevant articles and documents

Synthesis and Evaluation of Antileukemic Activity of 5-Thienyl- or 5-(2-Furyl)-2,3-dihydro-6,7-bis(hydroxymethyl)-1H-pyrrolizine Bis(alkylcarbamates) and Derivates

Treatment of N-(2-furoyl)proline (1a) or N-thenoylprolines (1b, 1c) and N-(2-thenoyl)thiazolidine-4-carboxylic acid (1d) with acetic anhydride and dimethyl acetylenedicarboxylate gave 5-substituted derivatives of dimethyl 2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate (2a, 2b, 2c) and derivatives of dimethyl 5-(2-thienyl)pyrrolothiazole (2d).Reduction of 2 with lithium aluminum hydride gave the diols 3a, 3b, 3c, and 3d.These diols yielded the corresponding diacetates 4 by treatment with acetic anhydride.The bis(methylcarbamates) 5a, 5b, 5c, and 5d and bis(isopropylcarbamates) 6b and 6c are obtained with the appropiate isocyanates.The 1-substituted pyrrolizines were synthesized, the 1-acetoxy compounds 7b and 7c further transformed into 1-hydroxy (8b, 8c) and 1-oxo (9b, 9c) analogues.The action of hydrochloric acid on 1-acetoxy derivatives (7b, 7c) gave 3H-pyrrolizines (10b, 10c).Evaluation of antileukemic activity was investigated on the leukemia L1210 in vivo, on several bis(alkylcarbamates).The compounds 5c and 5d show good antileukemic activity comparable with the mitomycin.