1179538-91-0Relevant academic research and scientific papers
Copper-catalyzed C-C bond formation through C-H functionalization: Synthesis of multisubstituted indoles from N-aryl enaminones
Bernini, Roberta,Fabrizi, Giancarlo,Sferrazza, Alessio,Cacchi, Sandro
supporting information; experimental part, p. 8078 - 8081 (2010/01/16)
A variety of functionalities, including the whole range of halogen substituents, are tolerated in the title reaction, an intramolecular approach for the construction of a multisubstituted indole skeleton from readily available enaminones (see scheme; phen=1,10-phenanthroline). The indole products are also prepared directly in high yield from α, β-ynones and primary amines.
3-Aroylindoles via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones
Bernini, Roberta,Cacchi, Sandro,Fabrizi, Giancarlo,Filisti, Eleonora,Sferrazza, Alessio
experimental part, p. 1480 - 1484 (2009/10/17)
3-Aroylindoles have been prepared via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones, readily available from 2-iodoanilines and α,β-ynones. The reaction tolerates a variety of useful functionalities including ether, keto, cyano, bromo, and chlor
