117970-29-3

Upstream product

• 117970-28-2 dl-2,4-dimethyl-4-hydroxy-6-oxo-1-cyclohexene-1-carboxylic acid 
• 117970-27-1 dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-5-methyl-3-oxo-1-cyclohexene-1-acetate 

Downstream Products

• 117970-31-7 (4R^*,6R^*)-1-methoxy(trimethylsilyloxy)methylene-4-methyl-2-methylene-4,6-bis(trimethylsilyloxy)cyclohexane 
• 117970-30-6 (4R^*,6R^*)-methyl 4,6-dihydroxy-2,4-dimethyl-1-cyclohexene-1-carboxylate 

Relevant academic research and scientific papers

SYNTHETIC STUDIES ON NOGALAMYCIN CONGENERS ; TOTAL SYNTHESES OF (+)-NOGARENE, (+)-7-DEOXYNOGAROL, AND (+)-7-CON-O-METHYLNOGAROL

According to the retrosynthetic perspective, the title total syntheses were accomplished by employing the regioselective Diels-Alder reactions of the (+)-naphthoquinone (5), the CDEF-ring system of nogalamycin congeners, with various structural types of dienes (8, 16, and 26).The highly functionalized dienes (16 and 26) incorporating all the functionalities present in the A-rings of (+)-7-deoxynogarol (3) and (+)-7-con-O-methylnogarol (2), were prepared efficiently by way of the 1,4-cyclohexadiene and 2-cyclohexanone derivatives (6 and 21), respectively.Reaction mechanism of the key Diels-Alder reaction was also discussed in terms of its stereoselectivity.