1179711-69-3Relevant academic research and scientific papers
Gold-catalyzed 1,2-difunctionalizations of aminoalkynes using only N- and O-containing oxidants
Mukherjee, Anupam,Dateer, Ramesh B.,Chaudhuri, Rupsha,Bhunia, Sabyasachi,Karad, Somnath Narayan,Liu, Rai-Shung
supporting information; experimental part, p. 15372 - 15375 (2011/11/07)
We report two viable routes for the 1,2-difunctionalization of aminoalkynes using only oxidants. In the presence of a gold catalyst, nitrones enable the oxoamination of aminoalkynes 1 to form 2-aminoamides 2. With a suitable gold catalyst, nitrosobenzenes implement an alkyne/nitroso metathesis of the same substrates to give 2-oxoiminylamides 3. These two novel oxidations also provide 1,2-aminoalcohols with opposite regioselectivity via NaBH4 reduction in situ.
