117976-91-7

Usage

Uses

Used in Pharmaceutical Industry:
Desmethyl rabeprazole thioether is used as a research compound for studying the pharmacokinetics and metabolism of rabeprazole. It helps in understanding the drug's absorption, distribution, metabolism, and excretion processes in the body, which is crucial for optimizing its therapeutic efficacy and safety.
Used in Drug Development:
Desmethyl rabeprazole thioether is utilized in the development of new drugs and drug formulations. By studying its properties and interactions, researchers can design more effective and safer medications for treating gastrointestinal disorders.
Used in Drug Interaction Studies:
Desmethyl rabeprazole thioether is employed in investigating potential drug-drug interactions. Understanding how it interacts with other medications can help healthcare professionals make informed decisions about drug combinations and dosing regimens, minimizing adverse effects and improving patient outcomes.
Used in Toxicology Research:
Desmethyl rabeprazole thioether is used as a tool in toxicology research to evaluate the safety profile of rabeprazole and its potential toxic effects. This information is vital for assessing the risk-benefit ratio of the drug and ensuring its safe use in clinical practice.

InChI:InChI=1/C17H19N3O2S/c1-12-15(18-8-7-16(12)22-10-4-9-21)11-23-17-19-13-5-2-3-6-14(13)20-17/h2-3,5-8,21H,4,9-11H2,1H3,(H,19,20)

Upstream product

• 134469-07-1 Benzimidazol-2-thiol 
• 117977-21-6 rabeprazole sulfide 

Relevant academic research and scientific papers

Amide-containing benzimidazole compound and application thereof (by machine translation)

The invention belongs to the technical field of medicines, and relates to 2 - [(pyridin -2 -ylmethyl) thio] - 111H-benzimidazole compounds as well as a preparation method and application. The general formula 2 - [(pyridin -2 -ylmethyl) thio] - 111H-benzimidazole compound and pharmaceutically acceptable salt are shown as follows: R1 , R2 The same or different, selected from hydrogen, C1 - C8 alkyl, C3 - C6 cycloalkyl, phenyl, halo substituted phenyl, C1 - C4 alkyl substituted phenyl, halo and C1 - C4 alkoxy at the same time substituted phenyl, halo substituted C1 C1 - C4 - C4 alkyl C1 - C4 substituted phenyl, benzyl, 4 - benzyloxyphenyl; or R1 , R2 A substituted or unsubstituted morpholinyl, phenylpiperazine or diphenylmethyl piperazine together with the nitrogen atom to which they are attached; the substituents are C1 - C4 alkoxy, C1 - C4 alkyl, halogen; R3 , R5 Self H, C1 - C4 alkyl. The compound is simple and convenient, is suitable for industrial production, and has obvious antitumor activity. (by machine translation)

Ureido-containing benzoimidazole compounds and application thereof

The invention belongs to the technical field of medicines, and relates to ureido-containing benzoimidazole compounds, a preparation method thereof, and an application of the ureido-containing benzoimidazole compounds in preparing medicines for anti-tumor

Synthesizing method of single-configuration rabeprazole metabolite

The invention discloses a synthesizing method of a single-configuration rabeprazole metabolite.According to the method, rabeprazole thioether serves as a starting material, and the rabeprazole metabolite is synthesized through a five-step reaction.The optimal preparation steps and reaction conditions are screened out through a large number of experiments, the whole technological design is reasonable, and the operability is high.According to the obtained single-configuration rabeprazole metabolite, the chemical purity can reach 99% or above, and the chiral purity is larger than 99.5%.The obtained single-configuration rabeprazole metabolite provides a standard substance for metabolic mechanism research of a rabeprazole drug, can be used for exploring the metabolic process of the drug in organisms and has a great application research value in clinical pharmacokinetic research.

PYRIDINE DERIVATIVES HAVING ANTI-ULCERATIVE ACTIVITY

Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are described.