1179809-05-2Relevant academic research and scientific papers
Thienopyrrole acetic acids as antagonists of the CRTH2 receptor
Bonafoux, Dominique,Abibi, Ayome,Bettencourt, Brian,Burchat, Andrew,Ericsson, Anna,Harris, Christopher M.,Kebede, Tegest,Morytko, Michael,McPherson, Michael,Wallace, Grier,Wu, Xiaoyun
, p. 1861 - 1864 (2011/05/05)
The bioisosteric replacement of the indole core of CRTH2 antagonists using thienopyrroles was investigated, resulting in potent antagonists with good selectivity over DP1. Early ADME/PK assessment of this chemotype demonstrated bioavailability in mice.
