117993-23-4

Usage

General Description

Benzenemethanol, 2-[(E)-[(2-hydroxyphenyl)methylene]amino]- is a chemical compound with the molecular formula C14H13NO2. It is also known as 2-((E)-((2-hydroxyphenyl)methylene)amino)benzenemethanol. Benzenemethanol, 2-[(E)-[(2-hydroxyphenyl)methylene]amino]- is a derivative of benzenemethanol and is commonly used in pharmaceutical research as a potential drug candidate. Its potential applications include as an antineoplastic agent, a histone deacetylase inhibitor, and an antineoplastic agent. Additionally, it is being studied for its potential role in treating breast cancer and other types of cancer.

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 90-02-8 salicylaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 

Relevant academic research and scientific papers

Synthesis and characterization of dibenzodioxazasiladecines

The reaction of N-(2-hydroxymethylphenyl)salicylideneimine with sodium hydride in dry toluene at -4°C produces 1,9-remote dianion. The cyclization of this dianion with diorganodichlorosilanes affords dibenzodioxazasiladecines in good yields. The products

Synthesis and comparative study of throe monomeric boronates by spectroscopic methods and X-ray crystallography

Three boronates have been synthesized by reaction of tridentate azomethine ligands derived from salicylaldehyde with phenylboronic acid. The [5.4.0], [4.4.0], and [4.3.0]heterobicyclic structures obtained have been characterized by NMR spectroscopy and X-

Synthesis of Chemically and Configurationally Stable Monofluoro Acylboronates: Effect of Ligand Structure on their Formation, Properties, and Reactivities

The recent disclosures of two classes of acylborons, potassium acyltrifluoroborates (KATs) and N-methyliminodiacetyl (MIDA) acylboronates, demonstrated that certain acylboron species can be both remarkably stable and uniquely reactive. Here we report new classes of ligands for acylboronates that have a significant influence on the formation, properties, and reactivities of acylboronates. Our systematic investigations identified a class of neutral, monofluoroboronates that can be prepared in a one step, gram-scale fashion from readily accessible KATs. These monofluoroboronates are stable to air, moisture, and silica gel chromatography and can be easily handled without any special precautions. X-ray crystallography, NMR spectroscopy, and HPLC studies showed that they are tetravalent, configurationally stable B-chiral acylboronates. Significantly, the ligands on the boronate allow for fine-tuning of the properties and reactivity of acylboronates. In amide-forming ligation with hydroxylamines under aqueous conditions, a considerable difference in reactivity was observed as a function of ligand structure. The solid-state structures suggested that subtle steric and conformational factors modulate the reactivities of the acylboronates.

Study of the Reaction of Tridentate Ligands with Ferrocenyl Boronic Acid

Evaluation of the reactivity of eight tridentate ligands derived from amino alcohols and salicylaldehyde, 2-hydroxyacetophenone, or 2-hydroxybenzophenone with ferrocenyl boronic acid has shown that the reaction leads to both monomeric and dimeric ferrocen

STEREOCHEMICAL STUDIES, 142. SATURATED HETEROCYCLES, 148 ONE-POT SYNTHESIS OF PARTIALLY SATURATED TETRACYCLIC BENZOXAZINES; SCOPE AND LIMITATIONS

The partly saturated 1,3-benzoxazinobenzoxazine (3) and 1,3-benzoxazinobenzoxazines (6a-c)were prepared in one-pot syntheses from trans-2-hydroxymethylcyclohexylamine (2) and trans-2-aminomethylcyclohexanol (5) via ring-chain tauto