118-28-5

Basic information

• Product Name: 5-amino-6-ethoxynaphthalene-2-sulphonic acid
• Synonyms: 5-amino-6-ethoxynaphthalene-2-sulphonic acid;5-AMINO-6-ETHOXY-2-NAPHTHALENE-SULFONIC ACID;C.I.38480;Ethoxy Cleve's Acid
• CAS NO: 118-28-5
• Molecular Formula: C₁₂H₁₃NO₄S
• Molecular Weight: 267.30092
• EINECS: 204-240-9
• Mol File: 118-28-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.3431 (rough estimate)
• Refractive Index: 1.6000 (estimate)
• CAS DataBase Reference: 5-amino-6-ethoxynaphthalene-2-sulphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-6-ethoxynaphthalene-2-sulphonic acid(118-28-5)
• EPA Substance Registry System: 5-amino-6-ethoxynaphthalene-2-sulphonic acid(118-28-5)

Safety Data

• Hazardous Substances Data: 118-28-5(Hazardous Substances Data)

Usage

General Description

5-amino-6-ethoxynaphthalene-2-sulphonic acid is a chemical compound with a molecular formula C12H13NO4S. It is an aromatic sulfonic acid with a naphthalene ring structure and an amino group. It is commonly used as a fluorescent probe for detecting proteins and amino acids, as well as for analyzing the binding of small molecules to proteins. It is also utilized in the preparation of fluorescent markers and dyes for biological and chemical research. Additionally, it has applications in the textile and paper industries as an acid dye and in the production of food colorants. However, it should be handled with care as it can be harmful if ingested or inhaled and may cause skin and eye irritation.

InChI:InChI=1/C12H13NO4S/c1-2-17-11-6-3-8-7-9(18(14,15)16)4-5-10(8)12(11)13/h3-7H,2,13H2,1H3,(H,14,15,16)

Downstream Products

• 93-01-6 2-naphthol-6-sulfonic acid 

Relevant articles and documents

Process for the preparation of 1-amino-2-ethoxy-naphthalene-6-sulphonic acid

A process for the preparation of 1-amino-2-ethoxy-naphthalene-6-sulphonic acid from 2-hydroxy-naphthalene-6-sulphonic acid which comprises: A. contacting 2-hydroxy-naphthalene-6-sulphonic acid with at least an equimolar amount of an alkali metal nitrite in aqueous solution or suspension in the presence of hydrochloric acid, solution or suspension having a pH in the range of 2 to 5 and being at a temperature of 0° to 20° C.; B. reducing the reaction product of step A in an aqueous suspension by contacting the same with excess iron in the presence of at least an equivalent amount of iron-II ions, relative to the reaction product obtained according to step A, in the presence of a mineral acid at a temperature from 50° to 120° C., and treating the thus-obtained reaction mixture with aqueous alkali metal hydroxide in the presence of iron oxide; C. contacting the product of step B with excess acetic anhydride in an aqueous solution or suspension at a pH in the range of 3 to 10 at a temperature from 0° to 100° C.; D. contacting the product of step C with an ethylating agent in the presence of an acid binding agent in an aqueous-organic solvent or diluent in a pH range from 8 to 14 at a temperature from 20° to 150° C.; and E. deacetylating the product of step D by contacting the same at reflux with an aqueous alkali metal hydroxide.