1180015-29-5Relevant articles and documents
4,5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES
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Page/Page column 11, (2009/09/05)
The present invention relates to a compounds of formula I wherein R1, R1′, R2, R3, R4, X, Ar, and m are as defined in the specification and claims and pharmaceutically active acid addition salts thereof. Compounds of the invention have Asp2 (β-secretase, BACE 1 or Memapsin-2) inhibitory activity and are useful for the treatment of diseases characterized by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.