118013-82-4Relevant academic research and scientific papers
An Aromatization Reaction of a 13α-Methyl Steroid
Hanson, James R.,Truneh, Almaz
, p. 2005 - 2008 (2007/10/02)
Whilst treatment of 6β,7β-dihydroxy-3α,5α-cycloandrostan-17-one with hydrogen bromide in glacial acetic acid affords, inter alia, the 13β,14β-cis-C/D-fused anthrasteriod, the corresponding 13α-methyl epimer affords the enantiomeric 13α,14α-anthrasteroid without isomerization at C-14.The stereochemistry of the anthrasteroid was established by n.O.e. measurements.Repetition using deuterium bromide led to extensive deuteriation.The major aromatic steroid that was formed in each case was an estratriene.
