118017-85-9Relevant articles and documents
A New Series of Tricyclic (Aryloximino)propanolamines Displaying Very High Selective β2-Blocking Properties
Jamart-Gregoire, Brigitte,Caubere, Paul,Blanc, Marie,Gnassounou, Jean-Pierre,Advenier, Charles
, p. 315 - 320 (2007/10/02)
A new class of indanones 4 easily obtained by aryne type condensations, followed by transposition of the benzocyclobutanols 3 thus formed, were transformed into the corresponding oximinopropanolamines 7.These compounds were studied for their potential β-blocking properties.It was found that 7 have generally low β1-blocking properties.Their β2-blocking action varies from low to very high.Interestingly one of them (7b) has the highest β2 activity/β1 activity (343) value known to date.