1180502-83-3Relevant academic research and scientific papers
Synthesis and biophysical properties of constrained d -altritol nucleic acids (cANA)
Migawa, Michael T.,Prakash, Thazha P.,Vasquez, Guillermo,Seth, Punit P.,Swayze, Eric E.
supporting information, p. 4316 - 4319 (2013/09/24)
The first synthesis of constrained altritol nucleic acids (cANA) containing antisense oligonucleotides (ASOs) was carried out to ascertain how conformationally restricting the d-altritol backbone-containing ASO (Me-ANA) would affect their ability to form duplexes with RNA. It was found that the thermal stability was reduced (cANA/RNA -1.1 C/modification) compared to DNA/RNA, suggesting the constrained system results in a small destabilizing perturbation in the duplex structure.
