118053-31-9

Upstream product

• 50-00-0 formaldehyd 
• 501330-86-5 2-acetyl-4-methyl-pentanoic acid benzyl ester 
• 5396-89-4 benzyl acetoacetate 
• 51951-27-0 2-isopropoxyisoindoline-1,3-dione 
• 89295-32-9 2-(ethoxycarbonyl)prop-2-en-1-yl phenyl sulfone 
• 75-30-9 2-iodo-propane 

Downstream Products

• 189163-64-2 [(RS)-2-[(benzyloxy)carbonyl]-4-methylpentyl]phosphinic acid 
• 1027225-38-2 (S)-2-[2-(Benzyl-methoxy-phosphinoylmethyl)-4-methyl-pentanoylamino]-propionic acid methyl ester 
• 189163-78-8 Benzyl-[2-(4-methoxy-phenylcarbamoyl)-4-methyl-pentyl]-phosphinic acid methyl ester 
• 189163-81-3 Benzyl-[2-(4-chloro-phenylcarbamoyl)-4-methyl-pentyl]-phosphinic acid methyl ester 
• 189163-74-4 Benzyl-(2-benzylcarbamoyl-4-methyl-pentyl)-phosphinic acid methyl ester 
• 189163-80-2 Benzyl-(4-methyl-2-phenylcarbamoyl-pentyl)-phosphinic acid methyl ester 
• 189163-87-9 benzyl[2-(N-benzylcarbamoyl)-4-methylpentyl]phosphinic acid 
• 189163-76-6 Benzyl-(2-dimethylcarbamoyl-4-methyl-pentyl)-phosphinic acid methyl ester 

Relevant academic research and scientific papers

Visible-Light-Mediated Manganese-Catalyzed Allylation Reactions of Unactivated Alkyl Iodides

Herein, we report a protocol for visible-light-mediated allylation reactions between unactivated alkyl iodides and allyl sulfones under mild conditions with catalysis by inexpensive and readily available Mn2(CO)10. This protocol is compatible with a wide array of sensitive functional groups and has a broad substrate scope with regard to both alkyl iodides and allyl sulfones.

Alkylation of Allyl/Alkenyl Sulfones by Deoxygenation of Alkoxyl Radicals

A challenging deoxygenation of alkoxyl radicals from readily accessible alcohol derivatives was developed, affording facile synthesis of functionalized alkenes with good functional group tolerance under mild reaction conditions. Because alkoxyl radicals can easily undergo β-fragmentations or hydrogen abstractions, this new strategy for deoxygenation of alkoxyl radicals is highly valuable. Moreover, mechanistic studies revealed that the electron-neutral phosphine acts as the deoxygenation reagent.

Efficient synthesis of enantiomerically pure β2-amino acids via chiral isoxazolidinones

We report a practical and scalable synthetic route for the preparation of α-substituted β-amino acids (β2-amino acids). Michael addition of a chiral hydroxylamine, derived from α-methylbenzylamine, to an α-alkylacrylate followed by cyclization gives a diastereomeric mixture of α-substituted isoxazolidinones. These diastereomers are separable by column chromatography. Subsequent hydrogenation of the purified isoxazolidinones followed by Fmoc protection affords enantiomerically pure Fmoc-β2-amino acids, which are useful for β-peptide synthesis. This route provides access to both enantiomers of a protected β2-amino acid.