1180536-37-1 Usage
Description
Ethyl 2-(2-bromophenyl)-2,2-difluoroacetate is a colorless liquid chemical compound with the molecular formula C10H8BrF2O2. It is derived from the esterification of 2-(2-bromophenyl)-2,2-difluoroacetic acid with ethanol and is known for its high reactivity and ability to participate in various organic reactions. Ethyl 2-(2-bromophenyl)-2,2-difluoroacetate has a faint odor and is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Due to its unique structure and functional groups, it also has potential applications in the field of medicinal chemistry. However, it is important to handle this compound with caution as it can be harmful if ingested or inhaled, and it may cause irritation upon contact with the skin or eyes.
Uses
Used in Pharmaceutical Industry:
Ethyl 2-(2-bromophenyl)-2,2-difluoroacetate is used as an intermediate in the synthesis of various pharmaceuticals for its high reactivity and ability to participate in various organic reactions.
Used in Agrochemical Industry:
Ethyl 2-(2-bromophenyl)-2,2-difluoroacetate is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective and efficient products for agricultural applications.
Used in Organic Synthesis:
Ethyl 2-(2-bromophenyl)-2,2-difluoroacetate is used as a versatile intermediate in organic synthesis due to its unique structure and functional groups, enabling the creation of a wide range of organic compounds.
Used in Medicinal Chemistry:
Ethyl 2-(2-bromophenyl)-2,2-difluoroacetate has potential applications in medicinal chemistry, where its unique structure and functional groups can be utilized for the development of new drugs and therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1180536-37-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,0,5,3 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1180536-37:
(9*1)+(8*1)+(7*8)+(6*0)+(5*5)+(4*3)+(3*6)+(2*3)+(1*7)=141
141 % 10 = 1
So 1180536-37-1 is a valid CAS Registry Number.
1180536-37-1Relevant articles and documents
Discovery of amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors for cancer immunotherapy
Zhang, Hongjun,Liu, Kun,Pu, Qinglin,Achab, Abdelghani,Ardolino, Michael J.,Cheng, Mangeng,Deng, Yongqi,Doty, Amy C.,Ferguson, Heidi,Fradera, Xavier,Knemeyer, Ian,Kurukulasuriya, Ravi,Lam, Yu-Hong,Lesburg, Charles A.,Martinot, Theodore A.,McGowan, Meredeth A.,Miller, J. Richard,Otte, Karin,Biju, Purakattle J.,Sciammetta, Nunzio,Solban, Nicolas,Yu, Wensheng,Zhou, Hua,Wang, Xiao,Bennett, David Jonathan,Han, Yongxin
, p. 1530 - 1536 (2019)
Checkpoint inhibitors have demonstrated unprecedented efficacy and are evolving to become standard of care for certain types of cancers. However, low overall response rates often hamper the broad utility and potential of these breakthrough therapies. Comb
SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5
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Paragraph 00352, (2020/10/19)
The disclosure is directed to methods of treatment using compounds of Formula (I).
NOVEL SUBSTITUTED N'-HYDROXYCARBAMIMIDOYL-1,2,5-OXADIAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS
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Page/Page column 47, (2018/03/25)
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
