118055-19-9Relevant articles and documents
Highly diastereoselective synthesis of 3-methylenetetrahydropyrans by palladium-catalyzed oxa-[4 + 2] cycloaddition of 2-alkenylbenzothiazoles
Ni, Qijian,Song, Xiaoxiao,Xu, Lei
supporting information, p. 6617 - 6621 (2020/09/21)
A highly diastereoselective synthesis of 3-methylenetetrahydropyrans via palladium-catalyzed oxa-[4 + 2] cycloaddition of 2-alkenylbenzothiazoles with allyl carbonates bearing a nucleophilic alcohol side chain is presented. This synthetic methodology tolerates a wide variety of 2-alkenylbenzothiazoles and afforded the desired 3-methylenetetrahydropyrans in good yields and excellent dr. In addition, further derivatizations resulted in new scaffolds, making them useful synthetic precursors.
Enantioselective Reaction between 2-(Cyanomethyl)azaarenes and N-Boc-amino Sulfones
Wang, Kezhou,Chen, Chao,Liu, Xihong,Li, Dan,Peng, Tianyu,Liu, Xin,Yang, Dongxu,Wang, Linqing
supporting information, p. 5260 - 5263 (2018/09/13)
A series of 2-(cyanomethyl)azaarenes containing benzothiazole or benzoxazole were designed and synthesized for asymmetric α-functionalization with N-Boc-amino sulfones. The Mannich adducts were obtained in high yields with good diastereo- and enantioselectivities. Aryl-substituted amino sulfones were tolerated under the current conditions, and the reaction can be performed on gram scale in good results.
