118062-06-9

Basic information

• Product Name: 2-methoxy-5-(2'-methoxyphenyl)cyclohepta-2,4,6-trien-1-one
• Synonyms: 2-methoxy-5-(2'-methoxyphenyl)cyclohepta-2,4,6-trien-1-one
• CAS NO: 118062-06-9
• Molecular Weight: 242.274
• Mol File: 118062-06-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-methoxy-5-(2'-methoxyphenyl)cyclohepta-2,4,6-trien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-5-(2'-methoxyphenyl)cyclohepta-2,4,6-trien-1-one(118062-06-9)
• EPA Substance Registry System: 2-methoxy-5-(2'-methoxyphenyl)cyclohepta-2,4,6-trien-1-one(118062-06-9)

Safety Data

• Hazardous Substances Data: 118062-06-9(Hazardous Substances Data)

Upstream product

• 578-57-4 2-bromoanisole 
• 17113-77-8 2-trimethylstannylanisole 
• 3172-00-7 5-bromotropolone 
• 77-78-1 dimethyl sulfate 
• 33816-51-2 5-bromo-2-methoxycyclohepta-2,4,6-trien-1-one 
• 5720-06-9 2-Methoxyphenylboronic acid 

Relevant articles and documents

Efforts directed toward the synthesis of colchicine: Application of palladium-catalyzed siloxane cross-coupling methodology

Colchicine is an important and synthetically challenging natural product. The key synthetic step in this approach to the synthesis of colchicine involved a palladium-catalyzed cross-coupling reaction between 5-bromotropolone (4) and an aryl siloxane to form the aryl-tropolone bond. The coupling of a variety of highly functionalized aryl siloxane derivatives was investigated and optimized coupling conditions were developed. It was discovered that a palladium catalyst with a high degree of phosphine ligand coordination (5 equiv of phosphine/mol Pd) was necessary to efficiently couple aryl siloxanes with 5-bromotropolone (4). In addition, the coupling approach has provided a direct comparison between siloxane and boronic acid coupling technologies that demonstrated that aryl siloxanes and boronic acids produce similar yields of highly functionalized biaryl products.

A NOVEL SYNTHESIS OF 5-ARYLTROPONE DERIVATIVES

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