118067-96-2

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 33522-63-3 3,4-methylenedioxyphenylalanine 
• 118067-87-1 (+/-)-2-azaisodeoxypodophyllotoxin 
• 147922-33-6 (-)-(S)-4-(3,4-methylenedioxybenzyl)-1,3-oxazolidin-2-one 
• 37002-51-0 (R)-2-amino-3-<3,4-(methylenedioxy)phenyl>propionic acid 
• 607742-47-2 (-)-(S)-3,4-methylenedioxyphenylalaninol 
• 124803-96-9 (+/-)-4-(3,4-methylenedioxybenzyl)-1,3-oxazolidin-2-one 
• 124803-97-0 (+/-)-3,4-methylenedioxyphenylalaninol 
• 118067-87-1 (+/-)-2-azadeoxypodophyllotoxin 

Relevant academic research and scientific papers

Podophyllotoxin aza-analogue, a novel DNA topoisomerase II inhibitor

The pendant E-ring moiety of the podophyllotoxin aza-analogue 1 that is a potent inhibitor of microtubule assembly was modified in order to acquire inhibitory activity of DNA topoisomerase II. The monophenolic analogue 2 did not exhibit human topoisomeras

Design, synthesis, and antitumor activity-absolute configuration relationships of podophyllotoxin aza-analogues

Optically active and racemic podophyllotoxin aza-analogues 3-7 were designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 10 or 16 with 3,4,5-trimethoxybenzaldehyde 11 and were found to show a promising in vitro a