118076-86-1Relevant academic research and scientific papers
α-amino-α(3-alkyl-phenyl)alkyl ethanoic acids wherein the 3-alkyl moiety bears a phosphorus oxo acid group or an ester thereof, their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
The invention discloses certain substituted α-aminoacids having the formula STR1 where m and n are 1 or 2, and R, R1, R2, R3 and Y have various significances, which compounds are useful in treating epilepsy, disorders associated with excess GH or LH secretion, anxiety, schizophrenia, depression, CNS degenerative disorders, cerebral hypoxic conditions and stress-related psychiatric disorders.
Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists
Bigge,Drummond,Johnson,Malone,Probert Jr.,Marcoux,Coughenour,Brahce
, p. 1580 - 1590 (2007/10/02)
To investigate the preferred spatial relationship of the distal phosphonic acid to the α-amino acid group of the established competitive N-methyl-D-aspartic acid (NMDA) antagonists APH (1) and APV (2), we have prepared a series of ortho-, meta-, and para-
