118079-35-9Relevant academic research and scientific papers
Inhibition of α-chymotrypsin with thiol-bearing substrate analogues in the presence of zinc ion
Han, Min Su,Oh, Dong Ju,Kim, Dong H.
, p. 701 - 705 (2004)
We have demonstrated that thiol-bearing analogues of α-chymotrysin (α-CT) substrates such as (S)-(1-benzyl-2-thiolethyl)-carbamic acid, benzyl ester (3) inhibits α-CT, a prototypical serine protease, in the presence of Zn(II) ion. They constitute a novel class of small molecule inhibitors for α-CT believed to inhibit the enzyme by forming a ternary complex consisting of α-CT, Zn(II) ion, and the inhibitor.
