118097-61-3Relevant academic research and scientific papers
Nickel-catalyzed 1,4-addition of trialkylboranes to α,β- unsaturated esters: Dramatic enhancement by addition of methanol
Hirano, Koji,Yorimitsu, Hideki,Oshima, Koichiro
, p. 1541 - 1544 (2008/02/02)
Equation presented Nickel catalyst systems for 1,4-addition of trialkylboranes to α,β-unsaturated esters have been developed. Addition of methanol was found to be essential for the alkylation reaction with 9-alkyl-9-BBNs.
Diastereoselective conjugate addition of 1-(α,β-unsaturated acyl)hydantoin with nucleophiles
Yamaguchi, Jun-Ichi,Harada, Masakazu,Narushima, Takao,Saitoh, Asumi,Nozaki, Kanako,Suyama, Takayuki
, p. 6411 - 6415 (2007/10/03)
A diastereomeric conjugate addition of dialkylaluminum chloride to 1-(α,β-unsaturated acyl)hydantoin provided the corresponding alkyl adduct with inducted chirality in the β-position. Treatment of 1-(α,β-unsaturated acyl)hydantoin with Gilman reagent in the presence of Lewis acid also gave the same product. In this reaction, diethylaluminum chloride was the most effective Lewis acid and the absolute configuration of the major adduct at the β-position of acyl group depended on the kinds of existing metals.
CHLORO- AND IODOTRIMETHYLSILANE-ACTIVATED ADDITIONS OF ORGANOCOPPER COMPOUNDS TO ENONES AND ENOATES
Bergdahl, Mikael,Lindstedt, Eva-Lotte,Nilsson, Martin,Olsson, Thomas
, p. 2055 - 2062 (2007/10/02)
Organocopper compounds add to enones and enoates in the presence of chloromethylsilane in ether giving the conjugate adducts in preparatively usefu yields via the silyl enol ethers.Presence of lithium iodide is important and excess of chlorotrimethylsilane accelerates the reactions.The combination of organocopper compound, iodotrimethylsilane and dimethyl sulfide gave faster reactions and very high yields, particularly in dichloromethane, where the reaction mixtures gradually became homogeneous.
