1181209-91-5Relevant academic research and scientific papers
Unconventional oxazole formation from isocyanides
Dos Santos, Aurelie,El Kaim, Laurent,Grimaud, Laurence,Ronsseray, Caroline
supporting information; experimental part, p. 3907 - 3909 (2009/12/08)
The coupling of an acyl chloride with an isocyanide affords 2,5-disubstituted oxazoles under mild basic conditions instead of 4,5-disubstituted derivatives when using Schoellkopf conditions (butyllithium); this reaction constitutes a remarkable example of a base-induced chemoselective process in isocyanide chemistry.
