1181219-07-7

Basic information

• Product Name: 2-(2-phenylethyl)-1,3,4-oxadiazole
• Synonyms: 2-(2-phenylethyl)-1,3,4-oxadiazole
• CAS NO: 1181219-07-7
• Molecular Weight: 174.202
• Mol File: 1181219-07-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2-phenylethyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenylethyl)-1,3,4-oxadiazole(1181219-07-7)
• EPA Substance Registry System: 2-(2-phenylethyl)-1,3,4-oxadiazole(1181219-07-7)

Safety Data

• Hazardous Substances Data: 1181219-07-7(Hazardous Substances Data)

Upstream product

• 3538-68-9 3-phenylpropanehydrazide 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 1181219-11-3 (E)-2-[1,2-bis(4-fluorophenyl)vinyl]-5-phenethyl-1,3,4-oxadiazole 
• 645-59-0 dihydrocinnamonitrile 
• 1380492-50-1 4-mesityl-3-phenethyl-4H-1,2,4-triazole 
• 1380492-57-8 4-tert-butyl-3-phenethyl-4H-1,2,4-triazole 
• 1380492-56-7 4-cyclohexyl-3-phenethyl-4H-1,2,4-triazole 
• 1380492-49-8 4-(2,6-diisopropylphenyl)-3-phenethyl-4H-1,2,4-triazole 
• 1386506-78-0 2-phenethyl-5-(2-phenyl-1H-indol-3-yl)-1,3,4-oxadiazole 
• 1354644-43-1 2-phenethyl-5-(2-phenyl-1H-indol-1-yl)-1,3,4-oxadiazole 
• 1309444-98-1 2-phenethyl-5-(2-phenylbenzofuran-3-yl)-1,3,4-oxadiazole 
• 1289639-19-5 (E)-2-(5-methyl-2-hexen-1-yl)-5-phenethyl-1,3,4-oxadiazole 
• 1261274-37-6 rac-S-methyl-S-phenyl-N-[5-(2-phenylethyl)-1,3,4-oxadiazol-2-yl]sulfoximine 
• 1225463-73-9 4-(5-phenethyl-1,3,4-oxadiazol-2-yl)morpholine 
• 1218811-74-5 2-[(4-methylphenyl)ethynyl]-5-phenethyl-1,3,4-oxadiazole 
• 1207551-81-2 2-phenethyl-5-(phenylethynyl)-1,3,4-oxadiazole 

Relevant articles and documents

Copper-Catalyzed Enantioconvergent Cross-Coupling of Racemic Alkyl Bromides with Azole C(sp2)?H Bonds

The development of enantioconvergent cross-coupling of racemic alkyl halides directly with heteroarene C(sp2)?H bonds has been impeded by the use of a base at elevated temperature that leads to racemization. We herein report a copper(I)/cinchona-alkaloid-derived N,N,P-ligand catalytic system that enables oxidative addition with racemic alkyl bromides under mild conditions. Thus, coupling with azole C(sp2)?H bonds has been achieved in high enantioselectivity, affording a number of potentially useful α-chiral alkylated azoles, such as 1,3,4-oxadiazoles, oxazoles, and benzo[d]oxazoles as well as 1,3,4-triazoles, for drug discovery. Mechanistic experiments indicated facile deprotonation of an azole C(sp2)?H bond and the involvement of alkyl radical species under the reaction conditions.

Nickel-catalyzed C-H alkenylation and alkylation of 1,3,4-oxadiazoles with alkynes and styrenes

(Chemical Equation Presented) The addition reaction of 1,3,4-oxadiazoles to alkynes via C-H bond cleavage efficiently proceeds in the presence of a nickel catalyst. This direct coupling allows a facile access to alkenyl-substituted oxadiazoles. The reaction with styrenes in place of alkynes is also available to selectively afford the corresponding branched adducts.