118135-28-7Relevant articles and documents
Synthesis method of 8-tert-butyl-2-chloromethyl-1, 4-dioxaspiro [4, 5] decane
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Paragraph 0041-0042, (2020/11/23)
The invention discloses a synthesis method of 8-tert-butyl-2-chloromethyl-1, 4-dioxaspiro [4, 5] decane, and the method comprises the following steps: dissolving p-tert-butyl cyclohexanone and epoxy chloropropane in an aprotic solvent, and performing reacting under the catalytic action of Lewis acid to obtain the 8-tert-butyl-2-chloromethyl-1, 4-dioxaspiro [4, 5] decane. According to the method, epoxy chloropropane with lower price is used for replacing 3-chloro-glycerol in a conventional route, so the production cost of the product is reduced; the method has the advantages of mild reaction conditions, high reaction selectivity and few side reaction impurities, and the product can reach high purity and yield, so the method is suitable for large-scale industrial production and application.