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CAS

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1181458-21-8

(4-Bromo-2-methoxy-6-methyl-phenyl)-amine hydrobromide is a chemical compound that consists of a bromine atom, a methoxy group, a methyl group, and an amine group attached to a phenyl ring. The hydrobromide form of (4-Bromo-2-methoxy-6-methyl-phenyl)-amine hydrobromide indicates that it is a salt derived from the reaction of the amine with hydrobromic acid. This chemical may have potential applications in the pharmaceutical or research fields, particularly in the development of new drugs or chemical reactions.
Used in Pharmaceutical Industry:
(4-Bromo-2-methoxy-6-methyl-phenyl)-amine hydrobromide is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure with a bromine atom, methoxy group, methyl group, and amine group attached to a phenyl ring may provide specific properties that can be utilized in the development of new drugs.
Used in Research Field:
(4-Bromo-2-methoxy-6-methyl-phenyl)-amine hydrobromide is used as a research compound for studying its chemical properties and potential applications. Its structure and reactivity can be further investigated through testing and research to explore its potential uses in various chemical reactions and processes.

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  • 1181458-21-8 Structure

  • Basic information

    1. Product Name: (4-Bromo-2-methoxy-6-methyl-phenyl)-amine hydrobromide
    2. Synonyms: (4-Bromo-2-methoxy-6-methyl-phenyl)-amine hydrobromide
    3. CAS NO:1181458-21-8
    4. Molecular Formula:
    5. Molecular Weight: 296.989
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1181458-21-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (4-Bromo-2-methoxy-6-methyl-phenyl)-amine hydrobromide(CAS DataBase Reference)
    10. NIST Chemistry Reference: (4-Bromo-2-methoxy-6-methyl-phenyl)-amine hydrobromide(1181458-21-8)
    11. EPA Substance Registry System: (4-Bromo-2-methoxy-6-methyl-phenyl)-amine hydrobromide(1181458-21-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1181458-21-8(Hazardous Substances Data)

1181458-21-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1181458-21-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,1,4,5 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1181458-21:
(9*1)+(8*1)+(7*8)+(6*1)+(5*4)+(4*5)+(3*8)+(2*2)+(1*1)=148
148 % 10 = 8
So 1181458-21-8 is a valid CAS Registry Number.

1181458-21-8Downstream Products

1181458-21-8Relevant articles and documents

Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents

Clark, Roger B.,He, Minsheng,Deng, Yonghong,Sun, Cuixiang,Chen, Chi-Li,Hunt, Diana K.,O'Brien, William J.,Fyfe, Corey,Grossman, Trudy H.,Sutcliffe, Joyce A.,Achorn, Catherine,Hogan, Philip C.,Katz, Christopher E.,Niu, John,Zhang, Wu-Yan,Zhu, Zhijian,Ronn, Magnus,Xiao, Xiao-Yi

, p. 8112 - 8138 (2013)

The C-8 position of the tetracyclines has been largely underexplored because of limitations in traditional semisynthetic techniques. Employing a total synthetic approach allowed for modifications at the C-7 and C-8 positions, enabling the generation of structure-activity relationships for overcoming the two most common tetracycline bacterial-resistance mechanisms: ribosomal protection (tet(M)) and efflux (tet(A)). Ultimately, several compounds were identified with balanced activity against both Gram-positive and Gram-negative bacteria, including pathogens bearing both types of tetracycline-resistance mechanisms. Compounds were screened in a murine systemic infection model to rapidly identify compounds with oral bioavailability, leading to the discovery of several compounds that exhibited efficacy when administered orally in murine pyelonephritis and pneumonia models.

Tetracycline compounds

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Page/Page column 181; 182; 183, (2016/05/19)

The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.

SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS

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Page/Page column 135, (2013/11/05)

The invention relates to substituted 4-aminobenzamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS

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Paragraph 0674, (2013/11/05)

Substituted 4-aminobenzamides, pharmaceutical compositions containing these compounds and also methods of using these compounds in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

TETRACYCLINE ANALOGS

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Page/Page column 62, (2012/03/09)

The present invention is directed to a compound represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.

POLYCYCLIC TETRACYCLINE COMPOUNDS

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Page/Page column 74-75, (2011/10/13)

The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.

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