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1181626-10-7

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1181626-10-7 Usage

Uses

2'',5''-Dimethylbiphenyl-3-carboxylic acid

Check Digit Verification of cas no

The CAS Registry Mumber 1181626-10-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,1,6,2 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1181626-10:
(9*1)+(8*1)+(7*8)+(6*1)+(5*6)+(4*2)+(3*6)+(2*1)+(1*0)=137
137 % 10 = 7
So 1181626-10-7 is a valid CAS Registry Number.

1181626-10-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,5-Dimethylbiphenyl-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names 3-(2,5-dimethylphenyl)benzoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1181626-10-7 SDS

1181626-10-7Downstream Products

1181626-10-7Relevant articles and documents

SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor

Urbano, Mariangela,Guerrero, Miguel,Zhao, Jian,Velaparthi, Subash,Schaeffer, Marie-Therese,Brown, Steven,Rosen, Hugh,Roberts, Edward

, p. 5470 - 5474 (2011/10/09)

Recent evidence suggests an innovative application of chemical modulators targeting the S1P4 receptor as novel mechanism-based drugs for the treatment of influenza virus infection. Modulation of the S1P4 receptor may also represent an alternative therapeutic approach for clinical conditions where reactive thrombocytosis is an undesired effect or increased megakaryopoiesis is required. With the exception of our recent research program disclosure, we are not aware of any selective S1P4 antagonists reported in the literature to date. Herein, we describe complementary structure-activity relationships (SAR) of the high-throughput screening (HTS)-derived hit 5-(2,5-dichlorophenyl)-N-(2,6-dimethylphenyl)furan-2- carboxamide and its 2,5-dimethylphenyl analog. Systematic structural modifications of the furan ring showed that both steric and electronic factors in this region have a significant impact on the potency. The furan moiety was successfully replaced with a thiophene or phenyl ring maintaining potency in the low nanomolar range and high selectivity against the other S1P receptor subtypes. By expanding the molecular diversity within the hit-derived class, our SAR study provides innovative small molecule potent and selective S1P 4 antagonists suitable for in vivo pharmacological validation of the target receptor.

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