1181635-75-5

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 112980-50-4 (E)-(S)-4-(tert-butyldimethylsilanyloxy)pent-2-enoic acid methyl ester 
• 87681-24-1 methyl (S)-2-(tert-butyldimethylsiloxy)propanoate 
• 994-30-9 triethylsilyl chloride 
• 1181635-85-7 (3S,4R,6S,7S)-7-(tert-butyldimethylsilyloxy)-3,6-dimethyl-1-(1-phenyl-1H-tetrazol-5-ylsulfonyl)octan-4-ol 
• 1181635-84-6 5-((3S,4R,6S,7S)-7-(tert-butyldimethylsilyloxy)-3,6-dimethyl-4-(triethylsilyloxy)octylthio)-1-phenyl-1H-tetrazole 
• 1181635-83-5 (3S,4R,6S,7S)-7-(tert-butyldimethylsilyloxy)-3,6-dimethyl-4-(triethylsilyloxy)octan-1-ol 
• 1181635-82-4 (5S,6S,8R)-8-((S)-but-3-en-2-yl)-10,10-diethyl-2,2,3,3,5,6-hexamethyl-4,9-dioxa-3,10-disiladodecane 
• 1181635-79-9 (3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-3-methylpentanoate 
• 1181635-81-3 (3S,4R,6S,7S)-7-(tert-butyldimethylsilyloxy)-3,6-dimethyloct-1-en-4-ol 
• 1181635-80-2 (3S,4S)-4-(tert-butyldimethylsilyloxy)-3-methylpentanal 

Downstream Products

• 1181635-71-1 (5R,9S,10R,12S,13S,E)-5-((4R,5R)-5-cyclohexyl-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-diethyl-5,9,12,13,15,15,16,16-octamethyl-10-(triethylsilyloxy)-4,14-dioxa-3,15-disilaheptadec-6-ene 

Relevant academic research and scientific papers

Synthesis of iriomoteolide-1a C13-C23 fragment via asymmetric conjugate addition and Julia-Kocienski coupling reaction

Image Presented The key C13-C23 fragment toward the total synthesis of iriomoteolide-1a (1) has been constructed from an 1,2-acetonide containing aldehyde 5 via a Julia-Kocienski olefination with the C16-C23 segment 6. The key step involves stereoselectiv