1181844-55-2Relevant academic research and scientific papers
Copper(II)-catalyzed C-C bond-forming reactions of α-electron- withdrawing group-substituted ketene S,S-acetals with carbonyl compounds and a facile synthesis of coumarins
Yuan, Hong-Juan,Wang, Mang,Liu, Ying-Jie,Liu, Qun
supporting information; experimental part, p. 112 - 116 (2009/08/07)
A new catalytic C-C bond-forming reaction has been developed. Catalyzed by cheap and commercially available copper(II) bromide (CuBr2; 10 mol%), the reactions of α-electron-withdrawing group (EWG)-substituted ketene S,S-acetals with aldehydes or ketones in acetonitrile at room temperature gave a variety of densely functionalized coupling products in excellent yields (80-98%). Based on this catalytic process, coumarin derivatives were efficiently synthesized when salicylaldehydes were selected as the carbonyl components.
