118206-00-1

Basic information

• Product Name: (R)-6,7-Dichloro-2,3-dihydro-benzofuran-2-carboxylic acid
• Synonyms: (R)-6,7-Dichloro-2,3-dihydro-benzofuran-2-carboxylic acid
• CAS NO: 118206-00-1
• Molecular Weight: 233.051
• Mol File: 118206-00-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-6,7-Dichloro-2,3-dihydro-benzofuran-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-6,7-Dichloro-2,3-dihydro-benzofuran-2-carboxylic acid(118206-00-1)
• EPA Substance Registry System: (R)-6,7-Dichloro-2,3-dihydro-benzofuran-2-carboxylic acid(118206-00-1)

Safety Data

• Hazardous Substances Data: 118206-00-1(Hazardous Substances Data)

Upstream product

• 118166-31-7 (1R,3R,4S)-p-menth-3-yl (R)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate 

Downstream Products

• 108940-98-3 (R)-6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydrobenzofuran-2-carboxylic acid 

Relevant articles and documents

Optical Resolution and Chiral Synthesis of Methyl 6,7-Dichloro-2,3-dihydrobenzofuran-2-carboxylate

Optical isomers of methyl 6,7-dichloro-2,3-dibenzofuran-2-carboxylate (2) were prepared by means of both optical resolution and chiral synthesis.The resolution of the carboxylic acid 3 was achieved in a practical and efficient way via the l- and d-menthyl esters, which were directly converted to enantiomers of 2.Chiral synthesis of 2 was attained with high optical yield via acid-catalyzed cyclization of the β-hydroxysulfide 10 derived from optically active glycidyl phenyl sulfide 13.The optical resolution method was considered to be better for large-scale preparation from the economical and operational viewpoints.Keywords - methyl 6,7-dichloro-2,3-dibenzofuran-2-carboxylate; optical resolution; (R)-4-phenyl-2-oxazolidone; menthol; chiral synthesis; glycidyl phenyl sulfide; β-hydroxysulfide; episulfonium ion; S-8666