118233-29-7Relevant academic research and scientific papers
Design and Synthesis of Potent, Selective, and Orally Active Fluorine-Containing Renin Inhibitors
Doherty, Annette M.,Sircar, Ila,Kornberg, Brian E.,Quin, John,Winters, Thomas R.,et al.
, p. 2 - 14 (2007/10/02)
A series of primate renin inhibitors containing difluorocarbinol and difluoroketone groups at the P1 - P1' position have been synthesized and studied both in vitro and in vivo.In vitro, the compounds were evaluated as inhibitors of m
1,2,4-Triazolopyrazine Derivatives with Human Renin Inhibitory Activity. 3. Synthesis and Biological Properties of Aminodeoxystatine and Difluorostatone Derivatives
Bradbury, Robert H.,Rivett, Janet E.
, p. 151 - 157 (2007/10/02)
Two series of 1,2,4-triazolopyrazine derivatives with human renin inhibitory activity have been synthesized which incorporate the transition-state mimetics (3S,4S)- and (3R,4S)-5-cyclohexyl-3,4-diaminopentanoic acid ((S)- and (R)-CDAPA), and (4S)-4
