118235-51-1

Basic information

• Product Name: 2-Propenal, 3-cyclopentyl-, (2E)-
• Synonyms: 2-Propenal, 3-cyclopentyl-, (2E)-;(2E)-3-cyclopentylacrylaldehyde;(E)-3-Cyclopentylpropenal;2-Propenal, 3-cyclopentyl-;(E)-3-cyclopentylacrylaldehyde
• CAS NO: 118235-51-1
• Molecular Formula: C₈H₁₂O
• Molecular Weight: 124.18028
• Mol File: 118235-51-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 198.4±9.0 °C(Predicted)
• Appearance: /
• Density: 1.018±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Propenal, 3-cyclopentyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenal, 3-cyclopentyl-, (2E)-(118235-51-1)
• EPA Substance Registry System: 2-Propenal, 3-cyclopentyl-, (2E)-(118235-51-1)

Safety Data

• Hazardous Substances Data: 118235-51-1(Hazardous Substances Data)

Usage

General Description

2-Propenal, 3-cyclopentyl-, (2E)- is a chemical compound with the molecular formula C9H12O. It is also known as (E)-3-Cyclopentylacrolein and is a colorless to pale yellow liquid with a strong, pungent odor. 2-Propenal, 3-cyclopentyl-, (2E)- is used as a chemical intermediate and in the production of organic compounds. It is also utilized in the manufacturing of pharmaceuticals, fragrances, and flavoring agents. However, it is important to handle this compound with care as it is classified as a hazardous substance and may pose health risks if not handled properly.

Upstream product

• 3054-95-3 acrylaldehyde diethyl acetal 
• 1556-18-9 cyclopentyl iodide 
• 872-53-7 cyclopentanealdehyde 
• 2136-75-6 (triphenylphosphoranylidene)acetaldehyde 
• 930-51-8 cyclopentylacetylene 
• 2769-64-4 n-butyl isonitrile 
• 154081-25-1 -3-cyclopentylprop-2-en-1-ol 

Downstream Products

• 1146629-82-4 (3R)-3-(4-bromo-1H-pyrazol-1-yl)-3-cyclopentylpropanal 
• 1259027-60-5 (R)-2-(cyclopentylidenemethyl)-3,3-bis(4-(dimethylamino)phenyl)propanal 
• 1259027-68-3 (E)-3-(1-(bis(4-(dimethylamino)phenyl)methyl)cyclopentyl)acrylaldehyde 

Relevant articles and documents

Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus

Diapophytoene desaturase (CrtN) is a potential novel target for intervening in the biosynthesis of the virulence factor staphyloxanthin. In this study, 38 1,4-benzodioxan-derived CrtN inhibitors were designed and synthesized to overwhelm the defects of leading compound 4a. Derivative 47 displayed superior pigment inhibitory activity, better hERG inhibitory properties and water solubility, and significantly sensitized MRSA strains to immune clearance in vitro. Notably, 47 displayed excellent efficacy against pigmented S. aureus Newman, Mu50 (vancomycin-intermediate MRSA, VISA), and NRS271 (linezolid-resistant MRSA, LRSA) comparable to that of linezolid and vancomycin in vivo.

Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo

Our previous work (Wang et al. J. Med. Chem. 2016, 59, 4831-4848) revealed that effective benzocycloalkane-derived staphyloxanthin inhibitors against methicillin-resistant Staphylococcus aureus (S. aureus) infections were accompanied by poor water solubility and high hERG inhibition and dosages (preadministration). In this study, 92 chroman and coumaran derivatives as novel inhibitors have been addressed for overcoming deficiencies above. Derivatives 69 and 105 displayed excellent pigment inhibitory activities and low hERG inhibition, along with improvement of solubility by salt type selection. The broad and significantly potent antibacterial spectra of 69 and 105 were displayed first with normal administration in the livers and hearts in mice against pigmented S. aureus Newman, Mu50 (vancomycin-intermediate S. aureus), and NRS271 (linezolid-resistant S. aureus), compared with linezolid and vancomycin. In summary, both 69 and 105 have the potential to be developed as good antibacterial candidates targeting virulence factors.

Enantioselective α-and γ-alkylation of α,β- unsaturated aldehydes using dienamine activation

The enantioselective alkylation of α,β-unsaturated aldehydes with stabilized carbocations as electrophiles via the activation as dienamine intermediates is described. This unique application of dienamine catalysis allows for the first enantioselective γ-a