118291-97-7Relevant academic research and scientific papers
Structure-based design and synthesis of lipophilic 2,4-diamino-6- substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents
Gangjee, Aleem,Vidwans, Anup P.,Vasudevan, Anil,Queener, Sherry F.,Kisliuk, Roy L.,Cody, Vivian,Li, Ruming,Galitsky, Nikolai,Luft, Joe R.,Pangborn, Walter
, p. 3426 - 3434 (2007/10/03)
The synthesis and biological activities of 14 6-substituted 2,4- diaminoquinazolines are reported. These compounds were designed to improve the cell penetration of a previously reported series of 2,4-diamino-6- substituted-pyrido[2,3-d]pyrimidines which h
