118315-14-3

Upstream product

• 118326-33-3 3-(1,4-dihydro-1-phenyl-<1>-benzothiopyrano<4,3-c>pyrazol-3-yl)-3-oxo-propanenitrile 
• 2909-38-8 m-chlorophenyl isocyanate 
• 118326-42-4 1,4-dihydro-1-phenyl-<1>-benzothiopyrano<4,3-c>pyrazole-3-carboxylic acid ethyl ester 
• 56876-58-5 3-ethoxalyl-2,3-dihydro-1-benzothiopyran-4-one 
• 3528-17-4 2,3-dihydro-4H-[1]benzothiopyran-4-one 

Relevant academic research and scientific papers

Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases

Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) STR1 wherein X represents an oxygen atom or a --CH(R4)--, --O--CH(R4)--, --S(O)n --CH(R4)--, --CH(R4)--O--, --CH(R4)--S(O)n -- --CH(R4)--CH2 -- group wherein n is 0, 1 or 2; R1 represents C1 -C6 alkyl, pyridyl or unsubstituted or substituted phenyl; R2, R3, and R4 are as herein defined; and Q is hydrogen, carboxy, C2 -C7 -alkoxycarbonyl or a --CON(Ra)Rb group, Ra and Rb being as defined herein; and their pharmaceutically acceptable salts are useful in the preparation of pharmaceutical compositions active in the treatment of autoimmune diseases.

Use of heteroaryl-3-oxo-propanenitrile derivatives in treating clinical wherein myelopoiesis suppression occurs

Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) STR1 wherein X represents an oxygen atom or a --CH(R4)--, --O--CH(R4)--,--S(O)n --, --S(O)n --CH(R4)--, --CH(R4)--O--, --CH(R4)--S(O)n -- or --CH(R4)--CH2 -- group wherein n is 0, 1 or 2; R1 represents C1 --C6 alkyl, pyridyl or unsubstituted or substituted phenyl; R2, R3 and R4 are as herein defined; and Q is hydrogen, carboxy, C2 -C7 - alkoxycarbonyl or a --CON(Ra)Rb group, Ra and Rb being as defined herein; and their pharmaceutically acceptable salts are useful in stimulating myelopoiesis in bone marrow suppressed mammals.

Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use

The invention relates to compounds having the general formula (I) STR1 and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the treatment of neoplastic diseases and acute and chronic infections of both bacterial and viral origin in mammals.