118374-59-7 Usage
General Description
CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT is a chemical compound used in biochemical and molecular biological research. It is a nucleotide analog that can be incorporated into RNA during transcription, allowing for the study of RNA synthesis and processing. The RP-isomer designation indicates the stereochemistry of the compound, specifying the arrangement of atoms around a phosphorus atom. The sodium salt form of this compound is the form commonly used in laboratory settings due to its increased stability and solubility. Overall, this chemical is an important tool for studying RNA and its role in various biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 118374-59-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,3,7 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 118374-59:
(8*1)+(7*1)+(6*8)+(5*3)+(4*7)+(3*4)+(2*5)+(1*9)=137
137 % 10 = 7
So 118374-59-7 is a valid CAS Registry Number.
118374-59-7Relevant articles and documents
Rapid and Efficient Synthesis of Nucleoside 5'-O-(1-Thiotriphosphates), 5'-Triphosphates and 2',3'-Cyclophosphorothioates Using 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one
Ludwig, Janos,Eckstein, Fritz
, p. 631 - 635 (2007/10/02)
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one phosphitylates the 5'-hydroxy group of a nucleoside to form an intermediate (2), which on subsequent reaction with pyrophosphate produces, in a double displacement process, a P2,P3-dioxo-P1-5'-nucleosidylcyclotriphophite (3).Oxidation with sulfur gives a nucleoside 5'-(1-thiocyclotriphosphate) (4), which is hydrolyzed to the diastereomeric mixture of a nucleoside 5'-O-(1-thiotriphosphate) (5).Alternatively, 3 can be oxidized with iodine/water to furnish nucleoside 5'-triphosphates 6.This reagent can also be applied to the synthesis of nucleoside 2',3'-cyclic phosphorothioates.Protection of nucleobase functional groups is not required.
