1184035-41-3Relevant academic research and scientific papers
An efficient approach to construct 2-arylbenzo[b]furans from 2-methoxychalcone epoxides
Ruan, Libo,Shi, Min,Mao, Shiwei,Yu, Lifang,Yang, Fan,Tang, Jie
, p. 1065 - 1070 (2014/01/23)
An efficient and practical method for construction of 2-arylbenzo[b]furans from 2-methoxychalcone epoxides has been reported. Catalyzed by 2 mol % of BF3·Et2O, 2-methoxychalcone epoxides went through the Meerwein rearrangement, followed by deformylation in one-pot to successfully afforded 2-methoxydeoxybenzoins. Afterward, 2-arylbenzo[b]furans were obtained in high yields (87%-100%) via intermolecular cyclodehydration of 2-methoxydeoxybenzoins with 48% HBr. By utilization of this approach, the natural product stemofuran A and the key intermediate of eupomatenoid 6 have been synthesized conveniently.
One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy
Wu, Guiyong,Yin, Weiyu,Shen, Hong C.,Huang, Yong
supporting information; experimental part, p. 580 - 585 (2012/04/23)
To access useful heterocycles in medicinal chemistry such as pyridazinones, dihydropyrimidinones, and dihydropyrimidinthiones, a "green" mild and highly efficient one-pot triple cascade was developed involving a Claisen-decarboxylation, electrophilic reaction, and subsequent heterocyclization. In addition, indazoles and benzofurans could also be constructed via a double cascade. To develop the cascade process, a direct Claisen-decarboxylation reaction was firstly optimized. This reaction can then couple with electrophilic reactions including alkylation, Michael addition or aldol reaction to enable the preparation of various aryl ketones in a one-pot fashion. The Royal Society of Chemistry 2012.
