118414-29-2Relevant academic research and scientific papers
Titanium as a Regio- and Stereo-selective Control Element in the Reaction of α-Alkoxyallylic Phosphine Oxide Anions with Carbonyl Compounds
Birse, Ewan F.,McKenzie, Alexander,Murray, Alistair W.
, p. 1039 - 1046 (2007/10/02)
A general method is described for directing the condensation of α-methoxyallylphosphine oxide anions (2) with aldehydes, preferentially at the α-position of the allyl system.The procedure, which employs the formation of the titanium ate complex, yields pure diastereoisomers with high stereoselectivity, and these can be used in Horner-Wittig reactions to provide an efficient and convenient synthesis of conjugated methoxydienes of defined geometry.Under the same conditions, acyl halides yield γ-adducts.
