118414-59-8 Usage
Uses
nTZDpa is a PPARγ agonist, with pharmaceutical applications such as anti-diabetic drugs.
Biological Activity
Potent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 118414-59-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,4,1 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 118414-59:
(8*1)+(7*1)+(6*8)+(5*4)+(4*1)+(3*4)+(2*5)+(1*9)=118
118 % 10 = 8
So 118414-59-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H15Cl2NO2S/c23-15-8-6-14(7-9-15)13-25-19-11-10-16(24)12-18(19)21(20(25)22(26)27)28-17-4-2-1-3-5-17/h1-12H,13H2,(H,26,27)
118414-59-8Relevant articles and documents
ANTIBACTERIAL COMPOUNDS
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, (2019/11/04)
The present application provides compounds of formula: Methods of using these compounds for killing bacterial growth and treating bacterial infections are also provided.
