118416-54-9

Upstream product

• 91331-37-2 5-chloro-2-phenyl-2H-benzotriazole 1-oxide 
• 91331-39-4 4-chloro-2-nitroazobenzene 
• 6141-95-3 trans-(4-chloro-phenyl)-phenyl-diazene 
• 98-95-3 nitrobenzene 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 62-53-3 aniline 
• 89284-65-1 4-chloro-2-nitro-1-nitrosobenzene 

Relevant academic research and scientific papers

Cu(I)/KOH-Promoted Condensation between o-Arylenediamines and Nitroarenes to Access 2-Aryl-2H-Benzotriazoles

Reported is the condensation between o-arylenediamines and nitroarenes enabled by a cooperative action of acid and base, providing a direct entry to 2-aryl-2H-benzotriazoles. The potential practicability of this methodology was demonstrated by 100 mmol-scale reactions and the synthesis of serotonin/dopamine receptor ligand and human growth hormone. (Figure presented.).

AgNO3 as nitrogen source for rhodium(III)-catalyzed synthesis of 2-aryl-2H -benzotriazoles from azobenzenes

A new approach has been established for Rh(iii)-catalyzed direct aza oxidative cyclization of non-prefunctionalized azobenzenes to provide 2-aryl-2H-benzotriazoles in good yields, in which AgNO3 instead of conventional azide reagents for the first time functions as the nitrogen source for the nitrogenation reaction. Preliminary mechanistic studies suggest that the Rh(iii)-catalyst could account for the nitration reaction, and subsequently cationic silver species might both play a vital role in the fission of the nitrogen-oxygen bonds in nitro groups and promote aza oxidative cyclization.

The Reaction of Some o-Nitroazobenzenes with Hydroxylamine

The reaction of some representative o-nitroazobenzenes with hydroxylamine in ethanolic sodium hydroxide solution gave good to excellent yields of the corresponding 2-aryl-2H-benzotriazole 1-oxides.In some cases, the corresponding parent 2-aryl-2H-benzotriazoles were also obtained.Under the same reaction conditions, nitrobenzene was essentially unreactive.It Is suggested that the reactive species is diimide.