1184175-49-2

Upstream product

• 56905-19-2 tert-butyl 2-iodopropanoate 
• 536-74-3 phenylacetylene 

Downstream Products

• 1184175-75-4 tert-butyl (S)-2,4-dimethyl-2-(phenylethynyl)pent-4-enoate 
• 1184175-72-1 tert-butyl (S)-2-methyl-2-(3-methylbenzyl)-4-phenylbut-3-ynoate 
• 189626-07-1 tert-butyl 2-methyl-4-phenylbuta-2,3-dienoate 
• 1184175-71-0 tert-butyl (S)-2-benzyl-2-methyl-4-phenylbut-3-ynoate 
• 1184175-74-3 tert-butyl (S)-2-(2-chlorobenzyl)-2-methyl-4-phenylbut-3-ynoate 
• 1184175-73-2 tert-butyl (S)-2-(4-methoxybenzyl)-2-methyl-4-phenylbut-3-ynoate 
• 1184175-76-5 tert-butyl (S)-2,4-dimethyl-2-(phenylethynyl)pent-4-enoate 

Relevant academic research and scientific papers

Palladium-Catalyzed Decarboxylative γ-Arylation for the Synthesis of Tetrasubstituted Chiral Allenes

An enantiospecific palladium-catalyzed decarboxylative coupling of acyclic β,γ-alkynoic acids with various aryl iodides to chiral tetrasubstituted allenes is described. The coupling reaction comprises a decarboxylative γ-palladation of α,α-disubstituted carboxylic acids to provide the tetrasubstituted allenes with complete point-to-axial chirality transfer in excellent yields.