1184184-87-9

Basic information

• Product Name: C₁₃H₁₀⁽²⁾HBrO
• CAS NO: 1184184-87-9
• Molecular Weight: 264.126
• Mol File: 1184184-87-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₀⁽²⁾HBrO(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₀⁽²⁾HBrO(1184184-87-9)
• EPA Substance Registry System: C₁₃H₁₀⁽²⁾HBrO(1184184-87-9)

Safety Data

• Hazardous Substances Data: 1184184-87-9(Hazardous Substances Data)

Upstream product

• 123335-02-4 bis-(2-bromophenyl)methanol 

Relevant articles and documents

The first asymmetric halogen/metal-exchange reaction: Desymmetrization of alcohols with enantiotopic bromoarene substituents

Desymmetrizations of the prochiral bis(bromoaryl)alcohols 1 and 4 were effected by treatment with iPr2Mg and enantiomerically pure lithium alkoxides. The resulting arylmagnesium compounds were quenched with various electrophiles. The absolute and (if relevant) relative configurations of the resulting products were determined. The best ee/yield combination was obtained for the protonolysis furnishing monobromoalcohol (R)-2 (53% ee, 51% yield). The latter was converted into (R)-orphenadrine, an antihistaminic and anticholinergic drug.