118420-38-5

Basic information

• Product Name: (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5-methoxy-pyridin-3-yl)-acrylamide
• Synonyms: (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5-methoxy-pyridin-3-yl)-acrylamide
• CAS NO: 118420-38-5
• Molecular Weight: 484.641
• Mol File: 118420-38-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5-methoxy-pyridin-3-yl)-acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5-methoxy-pyridin-3-yl)-acrylamide(118420-38-5)
• EPA Substance Registry System: (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5-methoxy-pyridin-3-yl)-acrylamide(118420-38-5)

Safety Data

• Hazardous Substances Data: 118420-38-5(Hazardous Substances Data)

Upstream product

• 20826-01-1 Ethyl 5-methoxynicotinate 
• 937202-11-4 (5-methoxypyridin-3-yl)methanol 
• 113118-83-5 5-methoxypyridine-3-carboxaldehyde 
• 101620-10-4 4-(4-diphenyl-methyl-1-piperazinyl)butylamine 
• 118419-99-1 (E)-3-(5-methoxypyridin-3-yl)acrylic acid 

Downstream Products

• 118420-39-6 N-[3-(5-hydroxy-3-pyridyl)acryloyl]4-(4-diphenylmethyl-1-piperazinyl)butylamine 

Relevant articles and documents

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

A new series of 3-(3-pyridyl)acrylamides 16, 17, 19, and 26, and 5-(3-pyridyl)-2,4-pentadienamides 20-25 were prepared and evaluated for their antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compounds 1a [(E)-N-[4 [4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamide] against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, 4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide (17p) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.