1184304-23-1

Basic information

• Product Name: 4-(4-butoxyphenylamino)-6-methyl-2-phenylpyridazin-3(2H)-one
• Synonyms: 4-(4-butoxyphenylamino)-6-methyl-2-phenylpyridazin-3(2H)-one
• CAS NO: 1184304-23-1
• Molecular Weight: 349.433
• Mol File: 1184304-23-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-butoxyphenylamino)-6-methyl-2-phenylpyridazin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-butoxyphenylamino)-6-methyl-2-phenylpyridazin-3(2H)-one(1184304-23-1)
• EPA Substance Registry System: 4-(4-butoxyphenylamino)-6-methyl-2-phenylpyridazin-3(2H)-one(1184304-23-1)

Safety Data

• Hazardous Substances Data: 1184304-23-1(Hazardous Substances Data)

Upstream product

• 54063-49-9 4-amino-6-methyl-2-phenyl-2H-pyridazin-3-one 
• 105365-51-3 4-butoxyphenylboronic acid 

Relevant articles and documents

6-Methyl-2,4-disubstituted pyridazin-3(2H)-ones: A novel class of small-molecule agonists for formyl peptide receptors

Following a ligand-based drug design approach, a potent mixed formyl peptide receptor 1 (FPR1) and formyl peptide receptor-like 1 (FPRL1) agonist (14a) and a potent and specific FPRL1 agonist (14x) were identified. These compounds belong to a large series of pyridazin-3(2H)-one derivatives substituted with a methyl group at position 6 and a methoxy benzyl at position 4. At position 2, an acetamide side chain is essential for activity. Likewise, the presence of lipophilic and/or electronegative substituents in the position para to the aryl group at the end of the chain plays a critical role for activity. Affinity forFPR1 receptors was evaluated by measuring intracellular calcium flux in HL-60 cells transfected with FPR1, FPRL1, and FPRL2. Agonists were able to activate intracellular calcium mobilization and chemotaxis in human neutrophils. Themost potent chemotactic agent (EC50 =0.6 μM) was the mixed FPR/FPRL1 agonist 14h.