118449-57-3

Basic information

• Product Name: 3-(4-BROMOPHENOXY)PROPANENITRILE
• Synonyms: BUTTPARK 51\07-14;3-(4-BROMOPHENOXY)PROPANENITRILE;3-(4-Bromophenoxy)propionitrile;Propanenitrile, 3-(4-bromophenoxy)-
• CAS NO: 118449-57-3
• Molecular Formula: C9H8BrNO
• Molecular Weight: 226.07
• Mol File: 118449-57-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(4-BROMOPHENOXY)PROPANENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BROMOPHENOXY)PROPANENITRILE(118449-57-3)
• EPA Substance Registry System: 3-(4-BROMOPHENOXY)PROPANENITRILE(118449-57-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 118449-57-3(Hazardous Substances Data)

Usage

General Description

3-(4-Bromophenoxy)propanenitrile is a chemical compound with the molecular formula C9H6BrNO. It is a nitrile derivative containing a 4-bromophenoxy group. 3-(4-BROMOPHENOXY)PROPANENITRILE is used in various chemical and pharmaceutical applications, including as a building block for the synthesis of other organic compounds. It is also used as an intermediate in the production of agrochemicals and pharmaceuticals. Additionally, 3-(4-bromophenoxy)propanenitrile may have potential uses in the field of material science and organic synthesis due to its unique chemical properties. As with all chemical compounds, proper handling and safety precautions should be taken when working with 3-(4-bromophenoxy)propanenitrile to minimize the risk of harm to human health and the environment.

Upstream product

• 106-41-2 4-bromo-phenol 
• 107-13-1 acrylonitrile 

Downstream Products

• 49660-57-3 6-bromochroman-4-one 
• 51483-92-2 6-bromo-1-benzopyran-4(4H)-one 
• 1017056-68-6 C₉H₁₁BrN₂O₂ 

Relevant articles and documents

Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones

3-Aryloxyproionic acids undergo intramolecular cyclization in the presence of AA.Mont.K-10 in toluene under reflux for 30–45 min in good to excellent yields. Phenyl ring bearing various substituents at the ortho, meta, para positions undergo this cyclization reaction. This method involves simple work up and amenable for large scale preparations. The heterogeneous acid treated catalyst can be regenerated and used for up to three cycles with minimum loss of activity.

An efficient synthesis of 4-chromanones

A two step efficient and practical synthesis of a variety of 4-chromanones is described. Phenols undergo a Michael addition to acrylonitriles in the presence of catalytic amounts of potassium carbonate and tert-butanol to generate the corresponding 3-aryloxypropanenitriles in 50-93% yields. Treatment of the resulting aryloxypropionitriles with 1.5 equiv of TfOH and 5 equiv of TFA, followed by an aqueous work up afforded 4-chromanones in moderate to excellent yields.