118452-02-1

Basic information

• Product Name: 2-AMINO-THIAZOLE-4-CARBOXYLAMIDE
• Synonyms: 2-aminothiazole-4-carboxamide;4-Thiazolecarboxamide,2-amino-(9CI);2-AMINOTHIAZOLE-4-CARBOXAMIDE,PURITY:97% MIN(HPLC);2-amino-1,3-thiazole-4-carboxamide;2-Amino-1,3-thiazole-4-carboamide
• CAS NO: 118452-02-1
• Molecular Formula: C₄H₅N₃OS
• Molecular Weight: 143.17
• Product Categories: AMIDE;Heterocyclic Compounds;pyridine
• Mol File: 118452-02-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 460.3 °C at 760 mmHg
• Flash Point: 232.2 °C
• Appearance: /Solid
• Density: 1.537 g/cm³
• Vapor Pressure: 1.18E-08mmHg at 25°C
• Refractive Index: 1.697
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Slightly, Sonicated), Methanol (Slightly)
• PKA: 15.14±0.50(Predicted)
• CAS DataBase Reference: 2-AMINO-THIAZOLE-4-CARBOXYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-THIAZOLE-4-CARBOXYLAMIDE(118452-02-1)
• EPA Substance Registry System: 2-AMINO-THIAZOLE-4-CARBOXYLAMIDE(118452-02-1)

Safety Data

• Hazardous Substances Data: 118452-02-1(Hazardous Substances Data)

Usage

Uses

2-Aminothiazole-4-carboxamide is a useful intermediate for organic synthesis and other chemical processes.

InChI:InChI=1/C4H5N3OS/c5-3(8)2-1-9-4(6)7-2/h1H,(H2,5,8)(H2,6,7)

Upstream product

• 118452-04-3 methyl 2-amino-1,3-thiazole-4-carboxylate 
• 5398-36-7 2-aminothiazole-4-carboxylate 

Downstream Products

• 879502-69-9 {[1-((S)-4-carbamoylthiazol-2-ylcarbamoyl)-2-phenylethylcarbamoyl]phenylmethyl}carbamic acid tert-butyl ester 

Relevant articles and documents

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN PREPARATION OF MEDICAMENTS FOR TREATING AND PREVENTING ANTIVIRAL DISEASES

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.

Synthesis of Certain Exocyclic Thiazole Nucleosides Related to Tiazofurin. Formation of a Unique Acycloaminonucleoside

Several thiazole nucleosides structurally related to tiazofurin (1) and ARPP (2) were prepared, in order to determine whether these nucleosides had enhanced antitumor/antiviral activities.Ring closure of 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)thiourea (