118458-60-9 Usage
Heterocyclic compound
It is a compound containing atoms of at least two different elements as part of a ring structure.
Fused ring structure
The compound has multiple rings that share two or more adjacent atoms, creating a complex and stable structure.
Contains two chlorine atoms
The presence of chlorine atoms contributes to the compound's reactivity and potential applications in various fields.
Carbonyl group
The compound features a carbonyl group (C=O), which is a common functional group in organic chemistry and can participate in various chemical reactions.
Pyrrolocarbazole derivative
It is classified as a derivative of the pyrrolocarbazole family, which is a group of compounds with potential biological and pharmaceutical properties.
Potential applications
The compound has potential uses in organic synthesis, medicinal chemistry, and materials science due to its unique molecular structure and potential pharmacological activities.
Starting material for synthesis
It can be used as a starting material for the synthesis of other related compounds, expanding the range of potential applications and products.
Investigation for biological and pharmaceutical properties
The compound's unique structure and potential activities make it a candidate for further research into its biological and pharmaceutical properties, which could lead to the development of new drugs or therapies.
These properties and specific content provide a comprehensive overview of the chemical compound 12,13-Dihydro-3,9-dichloro-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione and its potential significance in various scientific fields.
Check Digit Verification of cas no
The CAS Registry Mumber 118458-60-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,4,5 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 118458-60:
(8*1)+(7*1)+(6*8)+(5*4)+(4*5)+(3*8)+(2*6)+(1*0)=139
139 % 10 = 9
So 118458-60-9 is a valid CAS Registry Number.
118458-60-9Relevant academic research and scientific papers
Indolocarbazoles: Potent, selective inhibitors of human cytomegalovirus replication
Slater, Martin J.,Cockerill, Stuart,Baxter, Robert,Bonser, Robert W.,Gohil, Kam,Gowrie, Clare,Robinson, J. Edward,Littler, Edward,Parry, Nigel,Randall, Roger,Snowden, Wendy
, p. 1067 - 1074 (2007/10/03)
In our search for new, safer anti-HCMV agents, we discovered that the natural product Arcyriaflavin A (1a) was a potent inhibitor of HCMV replication in cell culture. A series of analogues (symmetrical indolocarbazoles) was synthesised to investigate structure-activity relationships in this series against a range of herpes viruses (HCMV, VZV, HSV1, and 2). This identified a number of novel, selective and potent inhibitors of HCMV, 12,13-dihydro-2,10-difluoro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-(6H)-dione (1d) being the best example (IC50=40nM, therapeutic index >1450). Compounds described in this series were generally poor inhibitors of protein kinase C βII, and no correlation was found between the ability to inhibit HCMV and the enzyme PKC. Copyright (C) 1999 Elsevier Science Ltd.
Further indole derivatives with antiviral activity
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, (2008/06/13)
The present invention relates to indolopyrolocarbazole derivatives, to their use in methods of treatment or prophylaxis of at least one viral infection or cardiovascular diseases; and pharmaceutical formulations containing such derivatives.
Synthesis of Indolopyrrolocarbazoles by Double Fischer Indolizations
Bergman, Jan,Pelcman, Benjamin
, p. 824 - 828 (2007/10/02)
A synthesis of indolopyrrolocarbazoles (16) based on a double Fisher indolization of the bis(phenylhydrazones) (10), employing polyphosphoric acid trimethylsilyl ester (PPSE) as the cyclization agent, is described.The bis(phenylhydrazones) (
